COMPLETE ANDROGEN BLOCKADE SAFELY ALLOWS FOR DELAY OF CYTOTOXIC CHEMOTHERAPY IN CASTRATION REFRACTORY PROSTATE CANCER

Complete androgen blockade safely allows for delay of cytotoxic chemotherapy in castration refractory prostate cancer

PURPOSE: Complete androgen blockade (CAB) does not prolong overall survival (OS) in patients with castration refractory prostate cancer (CRPC).Although there is variable clinical benefit with second-line hormone manipulation, we do not know which patients might benefit the most.OBJECTIVES: To identify clinical predictors of benefit of complete andr

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Research on eco-efficiency measurement, spatiotemporal analysis and prosperity warning based on the three-stage chain network SBM and MS-DDFM

This paper studies the changes of ecological efficiency (eco-efficiency) boom in China.Firstly, based on the improvement of the three-stage slack-based model Straws (SBM), a hybrid chain network model is used to clarify the internal development structure of eco-efficiency.Then, Taking eco-efficiency as the benchmark indicator, the boom warning indi

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A novel two-phase approach for solving the multi-compartment vehicle routing problem with a heterogeneous fleet of vehicles: a case study on fuel delivery

Distribution of goods is one of the main issues that directly affect the performance of the companies since efficient distribution of goods saves energy costs and also leads to reduced environmental impact.The multi-compartment vehicle routing problem (MCVRP) with a heterogeneous fleet of vehicles is encountered when dealing with this situation in

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